Chromosome 22q11. 2 deletion syndrome (22q11. 2del) is a complex, multi-organ disorder
noted for its varying severity and penetrance among those affected. The clinical problems …

Congenital heart defects (CHDs) are the most common type of birth defect occurring in% 1%
of live births1 and, if minor cardiac abnormalities such as bicuspid aortic valve are included …

The 22q11. 2 deletion syndrome is a multisystemic disorder characterized by a marked
variability of phenotypic features, making the diagnosis challenging for clinicians. The wide …

The functionality of chromatin is tightly regulated by post‐translational modifications that
modulate transcriptional output from target loci. Among the post‐translational modifications …

Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

Initially described as a triad of immunodeficiency, congenital heart defects and
hypoparathyroidism, 22q11. 2 deletion syndrome (22q11. 2DS) now encompasses a great …

The 22q11. 2 deletion is one of the most common genetic microdeletions, affecting
approximately 1 in 4000 live births in humans. A 1.5 to 2.5 Mb hemizygous deletion of …

Objective: Discuss evidence referring to the genetic role in congenital heart diseases,
whether chromosomic alterations or monogenic diseases. Data source: LILACS, PubMed …

Exposure to the emerging contaminant bisphenol A (BPA) is ubiquitous and associated with
cardiovascular disorders. BPA effect as endocrine disruptor is widely known but other …

Birth defects contribute to∼ 0.3% of global infant mortality in the first month of life, and
congenital heart disease (CHD) is the most common birth defect among newborns …