The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Transcription is the primary regulatory step in gene expression. Divergent transcription
initiation from promoters and enhancers produces stable RNAs from genes and unstable …

Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …

Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

Mammalian gene expression is inherently stochastic,, and results in discrete bursts of RNA
molecules that are synthesized from each allele,,,–. Although transcription is known to be …

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …

Background Colorectal cancer (CRC) is one of the most common malignant tumours. The
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …