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Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Design of polymeric carriers for intracellular peptide delivery in oncology applications
In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …
[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …
A smart “energy nanolock” selectively blocks oral cancer energy metabolism through synergistic inhibition of exogenous nutrient supply and endogenous energy …
Y Xu, X Zhang, A Zhou, C Cheng, K Chen… - Advanced …, 2023 - Wiley Online Library
The major challenge in oral cancer is the lack of state‐of‐the‐art treatment modality that
effectively cures cancer while preserving oral functions. Recent insights into tumor metabolic …
effectively cures cancer while preserving oral functions. Recent insights into tumor metabolic …
Advances in cancer treatment: a new therapeutic target, Annexin A2
Z Li, L Yu, B Hu, L Chen, M Jv, L Wang… - Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Annexin A2 (ANXA2) is a calcium regulated phospholipid-binding protein. It is expressed in
some tumor cells, endothelial cells, macrophages, and mononuclear cells, affecting cell …
some tumor cells, endothelial cells, macrophages, and mononuclear cells, affecting cell …
Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages
C Ngambenjawong, M Cieslewicz… - Journal of Controlled …, 2016 - Elsevier
The tumor microenvironment in the majority of cancers is known to favor polarization of
tumor-associated macrophages (TAMs) to alternatively activated M2 phenotype, promoting …
tumor-associated macrophages (TAMs) to alternatively activated M2 phenotype, promoting …
Origin of proteolytic stability of peptide-brush polymers as globular proteomimetics
Peptide-brush polymers (PBPs), wherein every side-chain of the polymers is peptidic,
represent a new class of proteomimetic with unusually high proteolytic resistance while …
represent a new class of proteomimetic with unusually high proteolytic resistance while …
Bottom-up strategies for the synthesis of peptide-based polymers
J Martin, A Desfoux, J Martinez, M Amblard… - Progress in Polymer …, 2021 - Elsevier
Thanks to their wide range of biological activities, peptides have been extensively used to
afford designed materials with tailored properties. Peptides can be associated to polymers …
afford designed materials with tailored properties. Peptides can be associated to polymers …
Molecular targeted treatment and drug delivery system for gastric cancer
L Jiang, X Gong, W Liao, N Lv, R Yan - Journal of Cancer Research and …, 2021 - Springer
Gastric cancer is still a major cancer worldwide. The early diagnosis rate of gastric cancer in
most high incidence countries is low. At present, the overall treatment effect of gastric cancer …
most high incidence countries is low. At present, the overall treatment effect of gastric cancer …
Adipose mesenchymal stem cells from osteoporotic donors preserve functionality and modulate systemic inflammatory microenvironment in osteoporotic cytotherapy
Maintenance of bone homeostasis against diseased microenvironments remains as a major
challenge. Recently, mesenchymal stem cells (MSCs) have been unravelled as potent …
challenge. Recently, mesenchymal stem cells (MSCs) have been unravelled as potent …