Mechanistic landscape of membrane-permeabilizing peptides

S Guha, J Ghimire, E Wu, WC Wimley - Chemical reviews, 2019 - ACS Publications
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Design of polymeric carriers for intracellular peptide delivery in oncology applications

S Lv, M Sylvestre, AN Prossnitz, LF Yang… - Chemical …, 2021 - ACS Publications
In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …

[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Biomedicine & …, 2023 - Elsevier
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

A smart “energy nanolock” selectively blocks oral cancer energy metabolism through synergistic inhibition of exogenous nutrient supply and endogenous energy …

Y Xu, X Zhang, A Zhou, C Cheng, K Chen… - Advanced …, 2023 - Wiley Online Library
The major challenge in oral cancer is the lack of state‐of‐the‐art treatment modality that
effectively cures cancer while preserving oral functions. Recent insights into tumor metabolic …

Advances in cancer treatment: a new therapeutic target, Annexin A2

Z Li, L Yu, B Hu, L Chen, M Jv, L Wang… - Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Annexin A2 (ANXA2) is a calcium regulated phospholipid-binding protein. It is expressed in
some tumor cells, endothelial cells, macrophages, and mononuclear cells, affecting cell …

Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

C Ngambenjawong, M Cieslewicz… - Journal of Controlled …, 2016 - Elsevier
The tumor microenvironment in the majority of cancers is known to favor polarization of
tumor-associated macrophages (TAMs) to alternatively activated M2 phenotype, promoting …

Origin of proteolytic stability of peptide-brush polymers as globular proteomimetics

H Sun, B Qiao, W Choi, N Hampu… - ACS Central …, 2021 - ACS Publications
Peptide-brush polymers (PBPs), wherein every side-chain of the polymers is peptidic,
represent a new class of proteomimetic with unusually high proteolytic resistance while …

Bottom-up strategies for the synthesis of peptide-based polymers

J Martin, A Desfoux, J Martinez, M Amblard… - Progress in Polymer …, 2021 - Elsevier
Thanks to their wide range of biological activities, peptides have been extensively used to
afford designed materials with tailored properties. Peptides can be associated to polymers …

Molecular targeted treatment and drug delivery system for gastric cancer

L Jiang, X Gong, W Liao, N Lv, R Yan - Journal of Cancer Research and …, 2021 - Springer
Gastric cancer is still a major cancer worldwide. The early diagnosis rate of gastric cancer in
most high incidence countries is low. At present, the overall treatment effect of gastric cancer …

Adipose mesenchymal stem cells from osteoporotic donors preserve functionality and modulate systemic inflammatory microenvironment in osteoporotic cytotherapy

CX Zheng, BD Sui, N Liu, CH Hu, T He, XY Zhang… - Scientific Reports, 2018 - nature.com
Maintenance of bone homeostasis against diseased microenvironments remains as a major
challenge. Recently, mesenchymal stem cells (MSCs) have been unravelled as potent …