The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

At the time of this writing, searching Google Scholar for 'light-sheet microscopy'returns
almost 8500 results; over three-quarters of which were published in the last 5 years alone …

Standard zebrafish transgenesis involves random transgene integration with resource-
intensive screening. While phiC31 integrase–based attP/attB recombination has streamlined …

The heart is the first functional organ to form during vertebrate development. Congenital
heart defects are the most common type of human birth defect, many originating as …

Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …

Despite its clinical and fundamental importance, our understanding of early human
development remains limited. Stem cell-derived, embryo-like structures (or embryoids) …

BACKGROUND: A main obstacle in current valvular heart disease research is the lack of
high-quality homogeneous functional heart valve cells. Human induced pluripotent stem …

Tendon is a vital connective tissue in human skeletal muscle system, and tendon injury is
very common and intractable in clinic. Tendon development and repair are two closely …

The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning …

Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and
progenitor cells (HSPCs). Recent data point to tissue-specific EC specialization as well as …