Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Das Kompendium der Psychiatrischen Pharmakotherapie liegt jetzt in der 14. Auflage vor.
Es ist in der Nachfolge der Psychiatrischen Pharmakotherapie, die von 1974–1996 in …

Background Resistant bipolar disorder is a major mental health problem related to
significant disability and overall cost. The aim of the current study was to perform a …

Aims To study the prevalence of fatigue and factors associated with fatigue in patients with
major depressive disorder (MDD) or bipolar disorder (BD). Methods Two hundred fifty-three …

Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and
sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored …

Objective The aim of this study was to evaluate the efficacy and safety of the dopaminergic‐
enhancing agent modafinil/armodafinil (MoArm) as adjunctive treatment for bipolar …

The dopamine transporter (DAT) is a membrane glycoprotein in dopaminergic neurons,
which modulates extracellular and intracellular dopamine levels. DAT is regulated by …

The treatment of bipolar depression is hampered by the inadequate efficacy of
antidepressants, moderate effect of mood stabilizers, and the side effects of some second …

BackgroundDepression and anxiety disorders (AD) are the first and sixth leading causes of
disability worldwide. Despite their high prevalence and significant disability resulted, there …