Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

Cytokines and chemokines involved in osteoarthritis pathogenesis

V Molnar, V Matišić, I Kodvanj, R Bjelica… - International journal of …, 2021 - mdpi.com
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

IL-6/JAK/STAT3 signaling in breast cancer metastasis: biology and treatment

SG Manore, DL Doheny, GL Wong, HW Lo - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities

M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Interleukin-6: a masterplayer in the cytokine network

P Uciechowski, W Dempke - Oncology, 2020 - karger.com
Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors

S Kaur, Y Bansal, R Kumar, G Bansal - Bioorganic & medicinal chemistry, 2020 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

M Del Giudice, SW Gangestad - Brain, behavior, and immunity, 2018 - Elsevier
Behavioral researchers have increasingly become interested in the idea that chronic, low-
grade inflammation is a pathway through which social and behavioral variables exert long …

Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

[HTML][HTML] The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer

A Masjedi, V Hashemi, M Hojjat-Farsangi… - Biomedicine & …, 2018 - Elsevier
Despite remarkable improvements in cancer treatment approaches, breast cancer is still the
main cause of cancer-related death in women. Its principal cause is the resistance of the …