Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …

The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and
metabolic state in response to nutrients, growth factors and many extracellular cues. Its …

As a substrate and major effector of the mammalian target of rapamycin complex 1
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Alternatively activated macrophages (M2) have an important function in innate immune
responses to parasitic helminths, and emerging evidence also indicates these cells are …

Metabolic dysfunction-associated fatty liver disease (MAFLD), proposed in 2020 is a novel
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …

Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …

Aims/hypothesis Mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator
of nutritional status at the cellular and organismic level. While mTORC1 mediates beta cell …

Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as
coronary artery disease and hypertension. Diminished glucose uptake due to impaired …

Although the role of hydrophilic antioxidants in the development of hepatic insulin resistance
and nonalcoholic fatty liver disease has been well studied, the role of lipophilic antioxidants …