Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Gene and nucleic acid therapy is expected to play a major role in the next generation of
agents for cancer treatment. We have recently developed a multifunctional envelope-type …

Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the
delivery of various drugs and drug candidates, including the promising therapeutic …

There are many potential barriers to the effective delivery of a drug in its active form to solid
tumors. Most small-molecule chemotherapeutic agents have a large volume of distribution …

The use of drug delivery systems (DDS) is an attractive approach to facilitate uptake of
therapeutic agents at the desired site of action, particularly when free drug has poor …

Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric
nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the …

Cell-penetrating peptides (CPPs) have been used to overcome the lipophilic barrier of the
cellular membranes and deliver large molecules and even small particles inside the cell for …

Many therapeutics require efficient cytosolic delivery either because the receptors for those
drugs are located in the cytosol or their site of action is an intracellular organelle that …

Strategies used to enhance liposome-mediated drug delivery in vivo include the
enhancement of stability and circulation time in the bloodstream, targeting to specific tissues …

Intracellular delivery of various drugs, including DNA, and drug carriers can sharply increase
the efficiency of various treatment protocols. However, the receptor-mediated endocytosis of …