Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke
I Daghlas, D Gill - Journal of Cerebral Blood Flow & …, 2024 - journals.sagepub.com
Discovery and development of efficacious and safe pharmacological therapies is fraught
with challenges. As proteins constitute the majority of drug targets and are encoded by …
with challenges. As proteins constitute the majority of drug targets and are encoded by …
Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study
D Qu, D Jiang, Y **n, G Yang, H Liang… - Frontiers in …, 2024 - frontiersin.org
Background Previous studies have shown that gut microbiota dysbiosis could affect clinical
prognosis through an unknown mechanism. However, the causal relationship between the …
prognosis through an unknown mechanism. However, the causal relationship between the …
Dual effects of serum urate on stroke risk and prognosis: insights from Mendelian randomization
S Chen, Z Chen, Q Xu, X Jiang, C Lin, J Ji - Frontiers in Neurology, 2024 - frontiersin.org
Background To investigate the causal associations of serum urate (SUA) with stroke risk and
prognosis using Mendelian randomization (MR) and the potential mediating role of stroke …
prognosis using Mendelian randomization (MR) and the potential mediating role of stroke …