Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

The pervasive role of the miR-181 family in development, neurodegeneration, and cancer

A Indrieri, S Carrella, P Carotenuto, S Banfi… - International journal of …, 2020 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the
regulation of gene expression. Evidence accumulating in the past decades indicate that they …

Detection of microRNA expression in human peripheral blood microvesicles

MP Hunter, N Ismail, X Zhang, BD Aguda, EJ Lee, L Yu… - PloS one, 2008 - journals.plos.org
Background MicroRNAs (miRNA) are small non-coding RNAs that regulate translation of
mRNA and protein. Loss or enhanced expression of miRNAs is associated with several …

Selective release of microRNA species from normal and malignant mammary epithelial cells

L Pigati, SCS Yaddanapudi, R Iyengar, DJ Kim… - PloS one, 2010 - journals.plos.org
MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …

MicroRNAs: new regulators of immune cell development and function

D Baltimore, MP Boldin, RM O'connell, DS Rao… - Nature …, 2008 - nature.com
Decades of research went into understanding immune cell development and function
without awareness that consideration of a key element, microRNA (miRNA), was lacking …

OncomiRs: the discovery and progress of microRNAs in cancers

WCS Cho - Molecular cancer, 2007 - Springer
Abstract microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding
RNA molecules of about 22 nucleotides in length that function as posttranscriptional gene …

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

F Pichiorri, SS Suh, M Ladetto, M Kuehl… - Proceedings of the …, 2008 - pnas.org
Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy,
has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs …

[HTML][HTML] Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE)

DJ Raiten, FAS Ashour, AC Ross, SN Meydani… - The Journal of …, 2015 - Elsevier
An increasing recognition has emerged of the complexities of the global health agenda—
specifically, the collision of infections and noncommunicable diseases and the dual burden …

Cancer chemoprevention by natural products: how far have we come?

RG Mehta, G Murillo, R Naithani, X Peng - Pharmaceutical research, 2010 - Springer
Since ancient times, natural products, herbs and spices have been used for preventing
several diseases, including cancer. The term chemoprevention was coined in the late 1970s …

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

Z Li, J Lu, M Sun, S Mi, H Zhang, RT Luo… - Proceedings of the …, 2008 - pnas.org
MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a
genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with …