Background Albuminuria is an early manifestation of sickle cell nephropathy. Prior small
case series suggests benefit of hydroxyurea in reducing albuminuria, with a similar trend …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor
outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis …

Abstract Background Hepatitis B virus (HBV) infections play an important role in the
development of hepatocellular carcinoma (HCC). HBV X protein (HBx) is a multifunctional …

The F-box protein FBXO31 is a tumor suppressor that is encoded in 16q24. 3, for which
there is loss of heterozygosity in various solid tumors. FBXO31 serves as the substrate …

The pleiotropic HBx oncoprotein of hepatitis B virus is well known to promote the expression
of ribosomal RNAs and several host proteins that are known to support the development and …

Background Renal damage is a progressive complication of sickle cell disease (SCD) that
begins in childhood and may progress to renal failure and early mortality in 12% of adults …

Hepatocellular carcinoma (HCC) is the most lethal cancer in the world. Hepatitis B virus
(HBV), hepatitis C virus (HCV), alcohol intake, and aflatoxin-B exposure have been …

Hepatitis B virus (HBV) is a global health problem. The HBV-mediated pathogenesis is a
multistep, multi-factorial event involving crucial interplay between the chronically persisting …

原发性肝癌(hepatocellular carcinoma, HCC) 是世界范围内最常见的恶性肿瘤之一,
其发病率位于所有癌症的第5 位, 死亡率为所有癌症的第3 位, 严重威胁着人类健康. 在诱发HCC …

AIM: To screen for genes related to metabotropic receptors that might be involved in the
development of chronic hepatitis. METHODS: Assessment of 20 genes associated with …