The interaction between microglia and astrocytes significantly influences neuroinflammation.
Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain …

Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …

Neuroinflammation has emerged as a major concern in ischemic stroke therapy because it
exacebates neurological dysfunction and suppresses neurological recovery after …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Ischemic stroke is one of the leading causes of mortality and disability worldwide. However,
there is a current lack of effective therapies available. As the resident macrophages of the …

The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Central nervous system (CNS) diseases have become one of the leading causes of death in
the global population. The pathogenesis of CNS diseases is complicated, so it is important …

Postoperative cognitive dysfunction (POCD) is a common neurological complication
following surgery and general anesthesia, especially in elderly patients. Severe cases delay …