There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Vaccines have been highly successful in the management of many diseases. However,
there are still numerous illnesses, both infectious and noncommunicable, for which there are …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and
significant health problem in the United States and worldwide. The mechanisms contributing …

Cell volume regulation is a primitive response to alterations in environmental osmolarity.
The NLRP3 inflammasome is a multiprotein complex that senses pathogen-and danger …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are innate immunity sensors that
provide an early/effective response to pathogenic or injury conditions. We have reported that …

Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension.
However, the stimuli and cellular mechanisms responsible for such inflammatory responses …

Inflammation is increasingly recognized as an important contributor to a host of CNS
disorders; however, its regulation in the brain is not well delineated. Nucleotide-binding …

Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …