Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Assessment and characterization of gut microbiota has become a major research area in
human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide …

Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …

We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …

The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …

METAL provides a computationally efficient tool for meta-analysis of genome-wide
association scans, which is a commonly used approach for improving power complex traits …

Type 2 diabetes is a serious and common chronic disease resulting from a complex
inheritance-environment interaction along with other risk factors such as obesity and …

There is increasing evidence that genome-wide association (GWA) studies represent a
powerful approach to the identification of genes involved in common human diseases. We …

Abstract The 1000 Genomes Project and disease-specific sequencing efforts are producing
large collections of haplotypes that can be used as reference panels for genotype imputation …