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Calcium and excitation-contraction coupling in the heart
Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Fundamentals of cellular calcium signaling: a primer
Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …
Methods in cardiomyocyte isolation, culture, and gene transfer
Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …
Cardiac T-tubule microanatomy and function
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
Na+/Ca2+ exchange and Na+/K+‐ATPase in the heart
This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …
University of California Davis Cardiovascular Symposium 2014: Systems approach to …
Calcium sparks
The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …
Calcium signaling in cardiac myocytes
Calcium (Ca2+) is a critical regulator of cardiac myocyte function. Principally, Ca2+ is the
link between the electrical signals that pervade the heart and contraction of the myocytes to …
link between the electrical signals that pervade the heart and contraction of the myocytes to …
T-tubule remodeling during transition from hypertrophy to heart failure
Rationale: The transverse tubule (T-tubule) system is the ultrastructural substrate for
excitation–contraction coupling in ventricular myocytes; T-tubule disorganization and loss …
excitation–contraction coupling in ventricular myocytes; T-tubule disorganization and loss …
Microengineered platforms for characterizing the contractile function of in vitro cardiac models
Emerging heart-on-a-chip platforms are promising approaches to establish cardiac
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …
High-speed optical imaging with sCMOS pixel reassignment
Fluorescence microscopy has undergone rapid advancements, offering unprecedented
visualization of biological events and shedding light on the intricate mechanisms governing …
visualization of biological events and shedding light on the intricate mechanisms governing …