Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Ultrasound is widely used for medical diagnosis and increasingly for therapeutic purposes.
An understanding of the bio-effects of sonography is important for clinicians and scientists …

Image-guided therapy (IGT) uses imaging to improve the localization and targeting of
diseased tissue and to monitor and control treatments. During the past decade, image …

Rationale: Focused ultrasound (FUS), in conjunction with circulating microbubbles (MBs),
can be used to transiently increase the permeability of the blood-brain barrier (BBB) in a …

Neurodegenerative diseases refer to disorders of the central nervous system (CNS) that are
caused by neuronal degradations, dysfunctions, or death. Alzheimer's disease, Parkinson's …

The central nervous system is protected by barriers which control the entry of compounds
into the brain, thereby regulating brain homeostasis. The blood–brain barrier, formed by the …

Brain stimulation methods are indispensable to the study of brain function. They have also
proven effective for treating some neurological disorders. Historically used for medical …