Metformin: update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Blautia—a new functional genus with potential probiotic properties?

X Liu, B Mao, J Gu, J Wu, S Cui, G Wang, J Zhao… - Gut …, 2021 - Taylor & Francis
Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the
feces and intestines of mammals. Based on phenotypic and phylogenetic analyses, some …

Metformin and its benefits for various diseases

Z Lv, Y Guo - Frontiers in endocrinology, 2020 - frontiersin.org
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

Shortcuts to adiabaticity: Concepts, methods, and applications

D Guéry-Odelin, A Ruschhaupt, A Kiely… - Reviews of Modern …, 2019 - APS
Shortcuts to adiabaticity (STA) are fast routes to the final results of slow, adiabatic changes
of the controlling parameters of a system. The shortcuts are designed by a set of analytical …

The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2019 - nature.com
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients

L Chen, B Liu, L Ren, H Du, C Fei, C Qian… - Frontiers in cellular …, 2023 - frontiersin.org
Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often
had the problems of fecal microbiota dysbiosis, and were usually accompanied with …

Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …

J Aron-Wisnewsky, MV Warmbrunn, M Nieuwdorp… - Gastroenterology, 2021 - Elsevier
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …

Spoof surface plasmon photonics

FJ Garcia-Vidal, AI Fernández-Domínguez… - Reviews of Modern …, 2022 - APS
In undergraduate courses on classical electromagnetism, it is taught that a perfect conductor
expels the electromagnetic (EM) field, and hence its surface is not able to support the …

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

L Sun, C **e, G Wang, Y Wu, Q Wu, X Wang, J Liu… - Nature medicine, 2018 - nature.com
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …