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Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Blautia—a new functional genus with potential probiotic properties?
X Liu, B Mao, J Gu, J Wu, S Cui, G Wang, J Zhao… - Gut …, 2021 - Taylor & Francis
Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the
feces and intestines of mammals. Based on phenotypic and phylogenetic analyses, some …
feces and intestines of mammals. Based on phenotypic and phylogenetic analyses, some …
Metformin and its benefits for various diseases
Z Lv, Y Guo - Frontiers in endocrinology, 2020 - frontiersin.org
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
Shortcuts to adiabaticity: Concepts, methods, and applications
Shortcuts to adiabaticity (STA) are fast routes to the final results of slow, adiabatic changes
of the controlling parameters of a system. The shortcuts are designed by a set of analytical …
of the controlling parameters of a system. The shortcuts are designed by a set of analytical …
The quest to slow ageing through drug discovery
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
L Chen, B Liu, L Ren, H Du, C Fei, C Qian… - Frontiers in cellular …, 2023 - frontiersin.org
Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often
had the problems of fecal microbiota dysbiosis, and were usually accompanied with …
had the problems of fecal microbiota dysbiosis, and were usually accompanied with …
Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …
J Aron-Wisnewsky, MV Warmbrunn, M Nieuwdorp… - Gastroenterology, 2021 - Elsevier
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …
Spoof surface plasmon photonics
In undergraduate courses on classical electromagnetism, it is taught that a perfect conductor
expels the electromagnetic (EM) field, and hence its surface is not able to support the …
expels the electromagnetic (EM) field, and hence its surface is not able to support the …
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …