Targeting the blood-brain barrier to prevent sepsis-associated cognitive impairment

DC Nwafor, AL Brichacek… - Journal of central …, 2019 - journals.sagepub.com
Sepsis is a systemic inflammatory disease resulting from an infection. This disorder affects
750 000 people annually in the United States and has a 62% rehospitalization rate. Septic …

Hearing, touching, and multisensory integration during mate choice

C Lenschow, ARP Mendes, SQ Lima - Frontiers in Neural Circuits, 2022 - frontiersin.org
Mate choice is a potent generator of diversity and a fundamental pillar for sexual selection
and evolution. Mate choice is a multistage affair, where complex sensory information and …

[HTML][HTML] Zinc as a therapy in a rat model of autism prenatally induced by valproic acid

LC Cezar, TB Kirsten, CCN da Fonseca… - Progress in neuro …, 2018 - Elsevier
Autism is characterized by numerous behavioral impairments, such as in communication,
socialization and cognition. Recent studies have suggested that valproic acid (VPA), an anti …

[HTML][HTML] Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway

X Jiang, J Liu, Q Lin, K Mao, F Tian, C **g, C Wang… - Brain research …, 2017 - Elsevier
Recent studies have demonstrated neuroinflammation and increased cytokine levels are
associated with depression. Aware of the efficacy the potential anti-inflammatory and …

Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration

CV Cardoso, MP de Barros, ALL Bachi… - Behavioural brain …, 2020 - Elsevier
Doxorubicin (DOX) is known to cause cognitive impairments in patients submitted to long-
term chemotherapy (deficits also known as chemobrain). The present study investigated …

Acute nicotine treatment attenuates lipopolysaccharide-induced cognitive dysfunction by increasing BDNF expression and inhibiting neuroinflammation in the rat …

P Wei, Q Liu, D Li, Q Zheng, J Zhou, J Li - Neuroscience letters, 2015 - Elsevier
Although nicotine has been shown to improve cognitive function in various studies, the
mechanisms underlying acute nicotine treatment-induced neuroprotection remain …

Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice

AA Chowdhury, NB Gawali, R Munshi… - Metabolic brain disease, 2018 - Springer
Neuroinflammation is said to play a pivotal role in the pathogenesis of neurodegenerative
disorders such as Alzheimer's disease (AD). Trigonelline (TRG) is a naturally occurring …

Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK-NF-κB pathway

X Jiang, G Wang, Q Lin, Z Tang, Q Yan, X Yu - Metabolic Brain Disease, 2019 - Springer
Fucoxanthin (FX), a natural carotenoid abundant in edible brown seaweeds, has been
shown the great anti-oxidant, anti-inflammatory and anti-diabetic effects in vivo and in vitro …

Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor …

MRAA Ali, AMH Abo-Youssef, BAS Messiha… - Naunyn-Schmiedeberg's …, 2016 - Springer
We aim to evaluate the protective role of the central angiotensin-converting enzyme (ACE)
inhibitor perindopril, compared with the standard reactive oxygen species (ROS) scavenger …

Propentofylline prevents sickness behavior and depressive-like behavior induced by lipopolysaccharide in rats via neuroinflammatory pathway

MMT Moraes, MC Galvao, D Cabral, CP Coelho… - PLoS …, 2017 - journals.plos.org
Recent studies have demonstrated the intimate relationship between depression and
immune disturbances. Aware of the efficacy limits of existing antidepressant drugs and the …