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Photocatalytic late-stage C–H functionalization
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …
significantly spurred innovative late-stage C–H functionalization approaches that make use …
Electrochemical late-stage functionalization
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …
diversification of novel molecular entities with improved physicochemical or biological …
Late-stage functionalization for improving drug-like molecular properties
NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
Late-stage C–H functionalization of azines
CM Josephitis, HMH Nguyen, A McNally - Chemical reviews, 2023 - ACS Publications
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …
Ligand‐to‐metal charge transfer (LMCT) photochemistry at 3d‐metal complexes: an emerging tool for sustainable organic synthesis
F Juliá - ChemCatChem, 2022 - Wiley Online Library
Despite the rich photochemistry of 3d‐metal complexes, the utilization of excited‐state
reactivity of these compounds in organic synthesis has been historically overlooked. The …
reactivity of these compounds in organic synthesis has been historically overlooked. The …
Applications of halogen-atom transfer (XAT) for the generation of carbon radicals in synthetic photochemistry and photocatalysis
The halogen-atom transfer (XAT) is one of the most important and applied processes for the
generation of carbon radicals in synthetic chemistry. In this review, we summarize and …
generation of carbon radicals in synthetic chemistry. In this review, we summarize and …
Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
Radical C(sp3)–H functionalization and cross-coupling reactions
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …
Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis
NES Tay, D Lehnherr, T Rovis - Chemical reviews, 2021 - ACS Publications
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …
Enantioselective radical reactions using chiral catalysts
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …
shown a continuous burst of new ideas and consequently a plethora of new catalytic …