Proposing novel natural compounds against Alzheimer's disease targeting acetylcholinesterase

M Girgin, S Isik, N Kantarci-Carsibasi - Plos one, 2023 - journals.plos.org
Alzheimer's disease (AD) is a neurodegenerative disorder considered as a global public
health threat influencing many people. Despite the concerning rise in the affected …

Medicinal Plants-A Promising Breakthrough in the Management of Alzheimer's Disease Progression Compared to NSAID: A Systematic Review

P Sugianto, W Ferriastuti, K Ritarwan… - Bali Medical …, 2022 - repository.unair.ac.id
Treatment of Alzheimer's Disease is currently limited only to slowing the progression of the
symptoms, not curing the disease. Current FDA-approved therapies such as Donepezil …

An In-silico Approach: Design, Homology Modeling, Molecular Docking, MM/GBSA Simulations, and ADMET Screening of Novel 1,3,4-oxadiazoles as PLK1inhibitors

S Malkaje, MG Srinivasa… - … : Current Drug Abuse …, 2023 - benthamdirect.com
Background: Breast cancer is the most commonly diagnosed and major cause of cancer-
related deaths in women worldwide. Disruption of the normal regulation of cell cycle …

Structure‐based design of new N‐benzyl‐piperidine derivatives as multitarget‐directed AChE/BuChE inhibitors for Alzheimer's disease

RA Conceição, N von Ranke, L Azevedo… - Journal of Cellular …, 2023 - Wiley Online Library
The pathogenic complexity of Alzheimer's disease (AD) demands the development of
multitarget‐directed agents aiming at improving actual pharmacotherapy. Based on the …

Revealing the Acetylcholinesterase Inhibitory Potential of Phyllanthus amarus and Its Phytoconstituents: In Vitro and in Silico Approach

KO Faloye, S Mahmud, EG Fakola… - … and biology insights, 2022 - journals.sagepub.com
The inhibition of acetylcholinesterase plays a vital role in the treatment of Alzheimer disease.
This study aimed to explore the acetylcholinesterase inhibition potential of Phyllanthus …

Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: a case study of Alzheimer's disease (AD …

SO Sofela, A Ibrahim, UC Ogbodo, DS Bodun… - In Silico …, 2024 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that affects
people aged 60 years and above. Yet, the discovery of potent therapeutic agents against …

Sappanin-type homoisoflavonoids from Scilla nervosa inhibits acetylcholinesterase enzyme: a combined in silico and in vitro approach

SO Famuyiwa, RB Patil, KO Faloye… - Journal of …, 2023 - Taylor & Francis
Alzheimer's disease is among the major health challenges that currently attract the attention
of health care givers and drug discovery and development experts worldwide. This study …

An In-silico Approach to Identify Potential Drug Molecules for Alzheimer's Disease: A Case Involving Four Therapeutic Targets

SSK Nair, RB Shafreen, SSN Al Maskari… - Letters in Drug …, 2022 - ingentaconnect.com
Background: Computational methods in the 'omics' era have proved to be a boon in the drug
discovery field. Bioinformatics and cheminformatics databases and tools complement the …

Computational screening of phytochemicals for anti-parasitic drug discovery

JH Zothantluanga, AK Umar, H Lalhlenmawia… - … Tools and Databases in …, 2023 - Elsevier
In silico techniques reduce the need for rigorous animal experimentations. It is time-efficient,
eco-friendly, sustainable, and also adheres to the principle of green chemistry. In silico …

[PDF][PDF] Traditional medicines and experimental analysis methods for Alzheimer's disease

HZ Kombo, S Kumar, G Singh - Tradit Med Res, 2022 - researchgate.net
Alzheimer's disease is a complex neurodegenerative ailment accompanied by cognitive
problems and progressive memory loss. The main causes of the disease are …