Cancer is a highly proliferative disease, which is caused due to the loss of regulation of cell
cycle and apoptosis, DNA damage, faulty repair system etc. The cancer microenvironment …

Liposomal peptide-based vaccines can potentially suppress cancer cells proliferation in the
host. To enhance the effectiveness of vaccination against cancer, additional strategies …

The main goal of peptide-based cancer vaccines is to induce the immune system and
activation of effective T cell responses against cancerous cells. Nevertheless, the potency of …

Lack of pre-existing tumor infiltrated T cells resulting in resistance to programmed cell death
protein 1 (PD-1) blockade therapies can be solved by combining with anti-cancer vaccines …

Despite significant recent improvements in the field of immunotherapy, cancer remains a
heavy burden on patients and healthcare systems. In recent years, immunotherapies have …

Background Targeting antigens to dendritic cells (DCs) via nanoparticles is a powerful
strategy which improves the efficacy of ex vivo antigen-pulsed DC vaccines. Methods In this …

Background The aims of this study included 3 aspects: 1) assessing the expression of
Apolipoprotein C1 (APOC1) in clear cell renal cell carcinoma (ccRCC) and normal groups; …

Objective (s): Program death 1 (PD-1)/program death-ligand 1 (PD-L1) pathways, as the
main inhibitory checkpoints, induce immunosuppression in the tumor microenvironment …

High expression of p32 in certain tumors makes it a potential target for immunotherapy. In
the present study, the first goal was to design multi-epitope peptides from the P32 protein …

Dendritic cell (DC) vaccination can be achieved via straight loading of vaccine into DCs ex
vivo or administration to DCs in vivo. However, there is no certain consensus on which …