AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
D Garcia, RJ Shaw - Molecular cell, 2017 - cell.com
AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …
during metabolic stress both at the cellular and physiological levels. The identification of …
AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley - Nature reviews Molecular cell biology, 2012 - nature.com
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …
falling energy status, it promotes ATP production by increasing the activity or expression of …
Oxidative stress and autophagy: the clash between damage and metabolic needs
Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
AMPK: sensing glucose as well as cellular energy status
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …
activated protein kinase (AMPK), which is activated when intracellular ATP production …
Cellular and molecular mechanisms of metformin: an overview
B Viollet, B Guigas, NS Garcia, J Leclerc… - Clinical …, 2012 - portlandpress.com
Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …
[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake
EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
AMP-activated protein kinase: the current landscape for drug development
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …
homeostasis, many exciting insights into its structure, regulation and physiological roles …
Fueling immunity: insights into metabolism and lymphocyte function
Background Naïve lymphocytes circulate in the body in a resting state, but upon recognition
of foreign antigen and receipt of proper costimulatory signals, these cells become activated …
of foreign antigen and receipt of proper costimulatory signals, these cells become activated …