The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis

B Fazzini, T Märkl, C Costas, M Blobner, SJ Schaller… - Critical care, 2023 - Springer
Background Patients with critical illness can lose more than 15% of muscle mass in one
week, and this can have long-term detrimental effects. However, there is currently no …

Skeletal muscle atrophy: From mechanisms to treatments

L Yin, N Li, W Jia, N Wang, M Liang, X Yang… - Pharmacological …, 2021 - Elsevier
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

ICU-acquired weakness

I Vanhorebeek, N Latronico, G Van den Berghe - Intensive care medicine, 2020 - Springer
Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired
weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk …

Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis

L Zhang, W Hu, Z Cai, J Liu, J Wu, Y Deng, K Yu… - PloS one, 2019 - journals.plos.org
Background Physical therapy can prevent functional impairments and improve the quality of
life of patients after hospital discharge. However, the effect of early mobilization on patients …

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

JM Cavaillon, M Singer, T Skirecki - EMBO molecular medicine, 2020 - embopress.org
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial

SJ Schaller, M Anstey, M Blobner, T Edrich, SD Grabitz… - The Lancet, 2016 - thelancet.com
Background Immobilisation predicts adverse outcomes in patients in the surgical intensive
care unit (SICU). Attempts to mobilise critically ill patients early after surgery are frequently …

Inspiratory muscle training for recovered COVID-19 patients after weaning from mechanical ventilation: a pilot control clinical study

AM Abodonya, WK Abdelbasset, EA Awad, IE Elalfy… - Medicine, 2021 - journals.lww.com
Background. To the best of our knowledge, no studies have evaluated the effects of
inspiratory muscle training (IMT) on recovered COVID-19 patients after weaning from …

Clinical review: intensive care unit acquired weakness

G Hermans, G Van den Berghe - Critical care, 2015 - Springer
A substantial number of patients admitted to the ICU because of an acute illness,
complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle …

Critical illness-associated diaphragm weakness

M Dres, EC Goligher, LMA Heunks, LJ Brochard - Intensive Care Medicine, 2017 - Springer
Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU
admission and may precipitate the need for mechanical ventilation but it also frequently …