New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Recent understanding of soil acidobacteria and their ecological significance: a critical review
Acidobacteria represents an underrepresented soil bacterial phylum whose members are
pervasive and copiously distributed across nearly all ecosystems. Acidobacterial sequences …
pervasive and copiously distributed across nearly all ecosystems. Acidobacterial sequences …
Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
Genomic features of bacterial adaptation to plants
A Levy, I Salas Gonzalez, M Mittelviefhaus… - Nature …, 2018 - nature.com
Plants intimately associate with diverse bacteria. Plant-associated bacteria have ostensibly
evolved genes that enable them to adapt to plant environments. However, the identities of …
evolved genes that enable them to adapt to plant environments. However, the identities of …
The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis
In soil ecosystems, microorganisms produce diverse secondary metabolites such as
antibiotics, antifungals and siderophores that mediate communication, competition and …
antibiotics, antifungals and siderophores that mediate communication, competition and …
Evolution and diversity of assembly-line polyketide synthases: Focus review
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …
machineries known in nature, responsible for the biosynthesis of numerous compounds …
IMG/M: integrated genome and metagenome comparative data analysis system
IMA Chen, VM Markowitz, K Chu… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Integrated Microbial Genomes with Microbiome Samples (IMG/M: https://img.
jgi. doe. gov/m/) system contains annotated DNA and RNA sequence data of (i) archaeal …
jgi. doe. gov/m/) system contains annotated DNA and RNA sequence data of (i) archaeal …
Computational approaches to natural product discovery
MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …
genome mining has been captivating: genomics and bioinformatics would transform …