New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Recent understanding of soil acidobacteria and their ecological significance: a critical review

S Kalam, A Basu, I Ahmad, RZ Sayyed… - Frontiers in …, 2020 - frontiersin.org
Acidobacteria represents an underrepresented soil bacterial phylum whose members are
pervasive and copiously distributed across nearly all ecosystems. Acidobacterial sequences …

Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

K Blin, T Wolf, MG Chevrette, X Lu… - Nucleic acids …, 2017 - academic.oup.com
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …

Genomic features of bacterial adaptation to plants

A Levy, I Salas Gonzalez, M Mittelviefhaus… - Nature …, 2018 - nature.com
Plants intimately associate with diverse bacteria. Plant-associated bacteria have ostensibly
evolved genes that enable them to adapt to plant environments. However, the identities of …

The evolution of genome mining in microbes–a review

N Ziemert, M Alanjary, T Weber - Natural product reports, 2016 - pubs.rsc.org
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis

A Crits-Christoph, S Diamond, CN Butterfield… - Nature, 2018 - nature.com
In soil ecosystems, microorganisms produce diverse secondary metabolites such as
antibiotics, antifungals and siderophores that mediate communication, competition and …

Evolution and diversity of assembly-line polyketide synthases: Focus review

A Nivina, KP Yuet, J Hsu, C Khosla - Chemical reviews, 2019 - ACS Publications
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

IMG/M: integrated genome and metagenome comparative data analysis system

IMA Chen, VM Markowitz, K Chu… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Integrated Microbial Genomes with Microbiome Samples (IMG/M: https://img.
jgi. doe. gov/m/) system contains annotated DNA and RNA sequence data of (i) archaeal …

Computational approaches to natural product discovery

MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …