Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Cerebral malaria is the most severe neurological complication of infection with Plasmodium
falciparum. With> 575,000 cases annually, children in sub-Saharan Africa are the most …

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10kDa (IP-
10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family …

Innate immune cells can potentiate the response to reinfection through an innate form of
immunological memory known as trained immunity. The potential of this fast-acting …

Malaria is a major cause of disease and death in tropical countries. A safe and effective
vaccine is essential to achieve significant and sustained reductions in malaria-related …

Malaria is possibly the most serious infectious disease of humans, infecting 5–10% of the
world's population, with 300–600 million clinical cases and more than 2 million deaths …

Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-
1 (HO-1, encoded by Hmox1) prevents the development of experimental cerebral malaria …

Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural
functions are increasingly recognized. The machinery of TGF-β signaling, including the …

▪ Abstract Immune responses can cause severe disease, despite the role immunity plays in
defending against parasitism. Indeed, immunopathology is a remarkably common cause of …