The intake of linoleic acid (LA) has increased dramatically in the standard American diet. LA
is generally promoted as supporting human health, but there exists controversy regarding …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

It is well known that oxidative stress and lipid peroxidation (LPO) play a role in physiology
and pathology. The most studied LPO product with pleiotropic capabilities is 4 …

Overnutrition and sedentary activity reinforce the growing trend of worldwide obesity, insulin
resistance, and type 2 diabetes. However, we have limited insight into how food intake …

Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …

Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …

Background Obesity is associated with an increased risk of insulin resistance and type 2
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …

Lipids can go through lipid peroxidation, an endogenous chain reaction that consists in the
oxidative degradation of lipids leading to the generation of a wide variety of highly reactive …

Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …