The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers
K San Tang - Life sciences, 2019 - Elsevier
Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and
cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model …
cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model …
Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
DJ Colacurcio, A Pensalfini, Y Jiang… - Free Radical Biology and …, 2018 - Elsevier
Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …
Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration
The endosome/lysosome pathway is disrupted early in the course of both Alzheimer's
disease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this …
disease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this …
The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors
Neurotrophins are a family of proteins that are important for neuronal development, neuronal
survival and neuronal functions. Neurotrophins exert their role by binding to their receptors …
survival and neuronal functions. Neurotrophins exert their role by binding to their receptors …
The emerging therapeutic role of NGF in Alzheimer's disease
CJ Xu, JL Wang, WL ** - Neurochemical research, 2016 - Springer
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that
affects the elderly population. Nerve growth factor (NGF) contributes to the survival …
affects the elderly population. Nerve growth factor (NGF) contributes to the survival …
The intersection of NGF/TrkA signaling and amyloid precursor protein processing in Alzheimer's disease neuropathology
N Canu, G Amadoro, V Triaca, V Latina… - International Journal of …, 2017 - mdpi.com
Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A
(TrkA) receptor has been suggested to contribute to the selective degeneration of basal …
(TrkA) receptor has been suggested to contribute to the selective degeneration of basal …
Research advances in huntingtin-associated protein 1 and its application prospects in diseases
Y Wu, Y Wang, Y Lu, J Yan, H Zhao, R Yang… - Frontiers in …, 2024 - frontiersin.org
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with
huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion …
huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion …
Butyrate promotes visceral hypersensitivity in an IBS‐like model via enteric glial cell‐derived nerve growth factor
X Long, M Li, LX Li, YY Sun, WX Zhang… - …, 2018 - Wiley Online Library
Background Altered visceral sensation is common in irritable bowel syndrome (IBS) and
nerve growth factor (NGF) participates in visceral pain development. Sodium butyrate (NaB) …
nerve growth factor (NGF) participates in visceral pain development. Sodium butyrate (NaB) …
Lignan-Rich Sesame (Sesamum indicum L.) Cultivar Exhibits In Vitro Anti-Cholinesterase Activity, Anti-Neurotoxicity in Amyloid-β Induced SH-SY5Y Cells, and …
MY Kim, S Kim, J Lee, JI Kim, E Oh, SW Kim, E Lee… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease, a major cause of dementia, is characterized by impaired cholinergic
function, increased oxidative stress, and amyloid cascade induction. Sesame lignans have …
function, increased oxidative stress, and amyloid cascade induction. Sesame lignans have …