Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …

The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in
all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex …

Negative regulation of immune pathways is essential to achieve resolution of immune
responses and to avoid excess inflammation. DNA stimulates type I IFN expression through …

Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …

The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …