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Antioxidant and oxidative stress: a mutual interplay in age-related diseases
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …
positively linked to cognitive and biological degeneration such as physical frailty …
The Nrf2/HO‐1 Axis as targets for flavanones: neuroprotection by pinocembrin, Naringenin, and Eriodictyol
Flavanones are a group of flavonoids that derive from their immediate chalcone precursors
through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4‐keto …
through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4‐keto …
Nrf2 as regulator of innate immunity: a molecular Swiss army knife!
Organisms are constantly exposed to a broad range of pathological and stress-inducing
agents, allergens and environmental chemicals that can induce infections, toxicity or other …
agents, allergens and environmental chemicals that can induce infections, toxicity or other …
[HTML][HTML] Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress
H Wang, X Liu, H Yang, X **g, W Wang, X Liu… - Life Sciences, 2023 - Elsevier
Aim The occurrence and progression of intervertebral disc degeneration (IDD) are
significantly influenced by the cartilaginous endplate (CEP). Pinocembrin (PIN), a type of …
significantly influenced by the cartilaginous endplate (CEP). Pinocembrin (PIN), a type of …
Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway
X Chen, W Wan, Y Guo, T Ye, Y Fo, Y Sun, C Qu… - Molecular …, 2021 - Springer
Background Oxidative stress is an important factor involved in the progress of heart failure.
The current study was performed to investigate whether pinocembrin was able to ameliorate …
The current study was performed to investigate whether pinocembrin was able to ameliorate …
Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity
H Lv, Q **ao, J Zhou, H Feng, G Liu, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by
overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2 …
overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2 …
α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2
B Huang, J Liu, S Fu, Y Zhang, Y Li, D He… - Frontiers in …, 2020 - frontiersin.org
α-Cyperone, extracted from Cyperus rotundus, has been reported to inhibit microglia-
mediated neuroinflammation. Oxidative stress and apoptosis play crucial roles in the course …
mediated neuroinflammation. Oxidative stress and apoptosis play crucial roles in the course …
Flavonoid-based nanomedicines in Alzheimer's disease therapeutics: Promises made, a long way to go
Alzheimer's disease (AD) is characterized by the continuous decline of the cognitive abilities
manifested due to the accumulation of large aggregates of amyloid-beta 42 (Aβ42), the …
manifested due to the accumulation of large aggregates of amyloid-beta 42 (Aβ42), the …
Pinocembrin suppresses oxidized low-density lipoprotein-triggered NLRP3 inflammasome/GSDMD-mediated endothelial cell pyroptosis through an Nrf2-dependent …
T Wang, H Tian, T Pan, S Yao, H Yu, Y Wu, S Wang - Scientific Reports, 2022 - nature.com
Pinocembrin (Pin) has been confirmed to exert anti-inflammatory and antiatherosclerotic
effects. Here we have explored whether and how Pin would protect vascular endothelial …
effects. Here we have explored whether and how Pin would protect vascular endothelial …
Sulforaphane promotes mitochondrial protection in SH-SY5Y cells exposed to hydrogen peroxide by an Nrf2-dependent mechanism
Abstract Sulforaphane (SFN; C 6 H 11 NOS 2) is an isothiocyanate found in cruciferous
vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti …
vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti …