Mechanisms of VEGF (vascular endothelial growth factor) inhibitor–associated hypertension and vascular disease
e2 Hypertension February 2018 target> 1 kinase receptor allowing for a broader indication
for use but with a greater potential for off-target effects. VSP inhibitors have been …
for use but with a greater potential for off-target effects. VSP inhibitors have been …
The causal relationship between endothelin-1 and hypertension: focusing on endothelial dysfunction, arterial stiffness, vascular remodeling, and blood pressure …
K Kostov - Life, 2021 - mdpi.com
Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most
important risk factors for cardiovascular and cerebrovascular complications. It is currently …
important risk factors for cardiovascular and cerebrovascular complications. It is currently …
Renal dysfunction, rather than nonrenal vascular dysfunction, mediates salt-induced hypertension
JE Hall - Circulation, 2016 - Am Heart Assoc
Hall Kidney Dysfunction in Salt-Induced Hypertension 895 induced experimentally or by
genetic mutations, has not been shown to increase salt sensitivity of BP. In this review, I …
genetic mutations, has not been shown to increase salt sensitivity of BP. In this review, I …
Salt-sensitivity of blood pressure and insulin resistance
Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular
morbidity and mortality that is seen in both hypertensive and normotensive populations …
morbidity and mortality that is seen in both hypertensive and normotensive populations …
Genetic engineering of lymphangiogenesis in skin does not affect blood pressure in mouse models of salt-sensitive hypertension
IM Thowsen, T Reikvam, T Skogstrand… - …, 2022 - Am Heart Assoc
Background: Recent studies have indicated that sodium storage is influenced by
macrophages that secrete VEGF-C (vascular endothelial growth factor) during salt stress …
macrophages that secrete VEGF-C (vascular endothelial growth factor) during salt stress …
Salt, water and nephron: Mechanisms of action and link to hypertension and chronic kidney disease
Q Qian - Nephrology, 2018 - Wiley Online Library
Our knowledge on sodium and water homeostasis and regulation continues to evolve. A
considerable amount of new information in this area has emerged in recent years. This …
considerable amount of new information in this area has emerged in recent years. This …
Endothelin‐1 in the pathophysiology of obesity and insulin resistance
HN Jenkins, O Rivera‐Gonzalez, Y Gibert… - Obesity …, 2020 - Wiley Online Library
The association between plasma endothelin‐1 (ET‐1) and obesity has been documented for
decades, yet the contribution of ET‐1 to risk factors associated with obesity is not fully …
decades, yet the contribution of ET‐1 to risk factors associated with obesity is not fully …
Aprocitentan and the endothelin system in resistant hypertension
M Clozel - Canadian Journal of Physiology and Pharmacology, 2022 - cdnsciencepub.com
Endothelin has emerged as a target for therapeutic intervention in systemic hypertension. As
a vasoconstrictor, comitogenic agent, linking pulse pressure and vascular remodeling, and …
a vasoconstrictor, comitogenic agent, linking pulse pressure and vascular remodeling, and …
Acclimation to a High‐Salt Diet Is Sex Dependent
Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …
complications than are men, yet the impact of sex on mechanisms regulating Na+ …
Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?
GR Abouelkheir, BD Upchurch… - … Biology and Medicine, 2017 - journals.sagepub.com
Lymphangiogenesis is a recognized hallmark of inflammatory processes in tissues and
organs as diverse as the skin, heart, bowel, and airways. In clinical and animal models …
organs as diverse as the skin, heart, bowel, and airways. In clinical and animal models …