The vitamin d receptor and T cell function
The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in
complex with hormonally active vitamin D, 1, 25 (OH) 2D3, regulates the expression of more …
complex with hormonally active vitamin D, 1, 25 (OH) 2D3, regulates the expression of more …
Vitamin D and outcomes in adult critically ill patients. A systematic review and meta-analysis of randomized trials
Purpose Low vitamin D blood levels are associated with high mortality in critically ill patients.
There is controversy about vitamin D supplementation in this population. The objective of …
There is controversy about vitamin D supplementation in this population. The objective of …
Novel insight into the role of the vitamin D receptor in the development and function of the immune system
J Arora, J Wang, V Weaver, Y Zhang… - The Journal of steroid …, 2022 - Elsevier
Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets. The
Vdr protein can be readily measured in the kidney using antibodies to the Vdr and western …
Vdr protein can be readily measured in the kidney using antibodies to the Vdr and western …
Vitamin D-binding protein controls T cell responses to vitamin D
Background In vitro studies have shown that the active form of vitamin D 3, 1a, 25-
dihydroxyvitamin D3 (1, 25 (OH) 2 D 3), can regulate differentiation of CD4+ T cells by …
dihydroxyvitamin D3 (1, 25 (OH) 2 D 3), can regulate differentiation of CD4+ T cells by …
Genomic effects of the vitamin D receptor: potentially the link between vitamin D, immune cells, and multiple sclerosis
Vitamin D has a plethora of functions that are important for the maintenance of general
health and in particular, the functional integrity of the immune system, such as promoting an …
health and in particular, the functional integrity of the immune system, such as promoting an …
Vitamin D in Cutaneous T-Cell Lymphoma
AWF Ødum, C Geisler - Cells, 2024 - mdpi.com
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells
in inflamed skin lesions. Mycosis fungoides (MF)—the most common variant of CTCL—often …
in inflamed skin lesions. Mycosis fungoides (MF)—the most common variant of CTCL—often …
Vitamin D Up-Regulates the Vitamin D Receptor by Protecting It from Proteasomal Degradation in Human CD4+ T Cells
The active form of vitamin D3, 1, 25 (OH) 2D3, has significant immunomodulatory properties
and is an important determinant in the differentiation of CD4+ effector T cells. The biological …
and is an important determinant in the differentiation of CD4+ effector T cells. The biological …
Deficiency in 25-hydroxyvitamin D and 30-day mortality in patients with severe sepsis and septic shock
MA Rech, T Hunsaker, J Rodriguez - American Journal of Critical Care, 2014 - AACN
Background Vitamin D has immunomodulating properties. Objective To determine if vitamin
D deficiency within 30 days of admission to the intensive care unit in patients with sepsis …
D deficiency within 30 days of admission to the intensive care unit in patients with sepsis …
Helicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses
L Guo, W Chen, H Zhu, Y Chen, X Wan, N Yang… - …, 2014 - Wiley Online Library
Abstract Background Vitamin D receptor (VDR) is a member of the nuclear receptor family of
transcription factors that play a critical role in innate immunity. This study examined the role …
transcription factors that play a critical role in innate immunity. This study examined the role …
Evolving role of vitamin D in immune-mediated disease and its implications in autoimmune hepatitis
AJ Czaja, AJ Montano-Loza - Digestive diseases and sciences, 2019 - Springer
Vitamin D has immunomodulatory, anti-inflammatory, antioxidant, and anti-fibrotic actions
that may impact on the occurrence and outcome of immune-mediated disease. The goals of …
that may impact on the occurrence and outcome of immune-mediated disease. The goals of …