Membrane homeostasis beyond fluidity: control of membrane compressibility
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …
compartmentalize biochemistry. They are actively remodeled in response to physical and …
Molecular shape solution for mesoscopic remodeling of cellular membranes
PV Bashkirov, PI Kuzmin, J Vera Lillo… - Annual review of …, 2022 - annualreviews.org
Cellular membranes self-assemble from and interact with various molecular species. Each
molecule locally shapes the lipid bilayer, the soft elastic core of cellular membranes. The …
molecule locally shapes the lipid bilayer, the soft elastic core of cellular membranes. The …
Molecular mechanism of GPCR spatial organization at the plasma membrane
G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their
spatial organization in plasma membrane (PM) domains is believed to encode signaling …
spatial organization in plasma membrane (PM) domains is believed to encode signaling …
WASP integrates substrate topology and cell polarity to guide neutrophil migration
To control their movement, cells need to coordinate actin assembly with the geometric
features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D …
features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D …
Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor
Abstract The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs
within the context of biased signaling. While the AT1 receptor is activated by agonists such …
within the context of biased signaling. While the AT1 receptor is activated by agonists such …
Recent developments in membrane curvature sensing and induction by proteins
Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …
to different local membrane curvatures, and these attributes are conserved across species …
Insights into membrane curvature sensing and membrane remodeling by intrinsically disordered proteins and protein regions
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate
their shape to perform various cellular functions. The protein's ability to sense membrane …
their shape to perform various cellular functions. The protein's ability to sense membrane …
Membrane shape as determinant of protein properties
JC Bozelli Jr, SS Aulakh, RM Epand - Biophysical Chemistry, 2021 - Elsevier
Membrane lipids play a role in the modulation of a variety of biological processes. This is
often achieved through fine-tuned changes in membrane physical and chemical properties …
often achieved through fine-tuned changes in membrane physical and chemical properties …
Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation
C Küey, M Sittewelle, G Larocque… - Elife, 2022 - elifesciences.org
The formation of a clathrin-coated vesicle (CCV) is a major membrane remodeling process
that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least …
that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least …
Remodeling of the plasma membrane by surface-bound protein monomers and oligomers: the critical role of intrinsically disordered regions
The plasma membrane (PM) of cells is a dynamic structure whose morphology and
composition is in constant flux. PM morphologic changes are particularly relevant for the …
composition is in constant flux. PM morphologic changes are particularly relevant for the …