Sjögren's syndrome: a systemic autoimmune disease
Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …
Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies
GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
Primary Sjögren's syndrome
Key Clinical Points Primary Sjögren's Syndrome A diagnosis of primary Sjögren's syndrome
is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes …
is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes …
Regulatory mechanism of M1/M2 macrophage polarization in the development of autoimmune diseases
Y Peng, M Zhou, H Yang, R Qu, Y Qiu… - Mediators of …, 2023 - Wiley Online Library
Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …
and organs. They are highly plastic and heterogeneous cells and can participate in the …
Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …
Type I interferon in rheumatic diseases
TLW Muskardin, TB Niewold - Nature reviews rheumatology, 2018 - nature.com
The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …
Type I interferon in the pathogenesis of lupus
Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment
FB Vivino, VY Bunya… - Clinical …, 2019 - pubmed.ncbi.nlm.nih.gov
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment …
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment …
[HTML][HTML] Mucosal immunology of the ocular surface
The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …
Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
An abnormal neutrophil subset has been identified in the PBMC fractions from lupus
patients. We have proposed that these low-density granulocytes (LDGs) play an important …
patients. We have proposed that these low-density granulocytes (LDGs) play an important …