Cancer genomic instability contributes to the phenomenon of intratumoral genetic
heterogeneity, provides the genetic diversity required for natural selection, and enables the …

5.1. 5. Error thresholds in finite populations 241 5.1. 6. Clues from the real world 244 5.2.
Muller's ratchet 245 5.2. 1. Ratchet dynamics 246 5.2. 2. Error thresholds versus Muller's …

This discussion attempts to present a simple explanation of the current theory of error
catastrophe and why it does not herald a paradigm shift in antiviral strategy. In the main text …

It is a common mistake to view cancer as a single disease with a single possible cure which
we have just not found yet. In reality cancer takes on many forms that share a common …

When mutation rates are low, natural selection remains effective, and increasing the
mutation rate can give rise to an increase in adaptation rate. When mutation rates are high to …

Beneficial mutations drive adaptive evolution, yet their selective advantage does not ensure
their fixation. Haldane's application of single-type branching process theory showed that …

Mutagenic drugs are promising candidates for the treatment of various RNA virus infections.
Increasing the mutation rate of the virus leads to rapid accumulation of deleterious mutation …

Using as a narrative theme the example of Darwin's finches, a microscopic agent-based
model is introduces to study sympatric speciation as a result of competition for resources in …

We discovered a dynamic phase transition induced by sexual reproduction. The dynamics is
a pure Darwinian rule applied to diploid bit-strings with both fundamental ingredients to …

In this review some simple models of asexual populations evolving on smooth landscapes
are studied. The basic model is based on a cellular automaton, which is analyzed here in …