Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-
celled yeast to mammals. Here, we report the use of recent techniques in nutrition research …

Evolutionary theory is firmly grounded on the existence of trade-offs between life-history
traits, and recent interest has centred on the physiological mechanisms underlying such …

Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that
a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in …

Long‐term caloric restriction (CR) is a robust means of reducing age‐related diseases and
extending life span in multiple species, but the effects in humans are unknown. The low …

Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a
larger effect in females than males. Traditionally, this has been attributed to a stronger trade …

Mitochondria play a wide diversity of roles in cell physiology and have a key functional
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …

The mitochondrial free radical theory of aging is reviewed. Only two parameters currently
correlate with species longevity in the right sense: the mitochondrial rate of reactive oxygen …

Enhanced oxidative stress is closely related to aging and impaired metabolic health and is
influenced by diet-derived nutrients and energy. Recent studies have shown that methionine …