Fighting bacterial persistence: current and emerging anti-persister strategies and therapeutics

V Defraine, M Fauvart, J Michiels - Drug Resistance Updates, 2018 - Elsevier
In addition to the well-known strategies of antibiotic resistance and biofilm formation,
bacterial populations possess an additional survival strategy to endure hostile environments …

Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms

L Grassi, G Maisetta, S Esin, G Batoni - Frontiers in microbiology, 2017 - frontiersin.org
The great clinical significance of biofilm-associated infections and their inherent
recalcitrance to antibiotic treatment urgently demand the development of novel antibiofilm …

1, 3, 5-Triazines: A promising scaffold for anticancer drugs development

S Cascioferro, B Parrino, V Spanò, A Carbone… - European journal of …, 2017 - Elsevier
This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …

Scanning ion conductance microscopy reveals differences in the ionic environments of gram-positive and negative bacteria

K Cremin, BA Jones, J Teahan, GN Meloni… - Analytical …, 2020 - ACS Publications
This paper reports on the use of scanning ion conductance microscopy (SICM) to locally
map the ionic properties and charge environment of two live bacterial strains: the Gram …

Peptide-based strategies for overcoming biofilm-associated infections: A comprehensive review

T Manobala - Critical Reviews in Microbiology, 2024 - Taylor & Francis
Biofilms represent resilient microbial communities responsible for inducing chronic
infections in human subjects. Given the escalating challenges associated with antibiotic …

Novel sulfonamide–triazine hybrid derivatives: docking, synthesis, and biological evaluation as anticancer agents

MA Alelaimat, MA Al-Sha'er, HA Basheer - ACS omega, 2023 - ACS Publications
The biological benefits of trisubstituted 1, 3, 5-triazine derivatives include their ability to
reduce inflammation and fight cancer. A unique series of sulfonamide–triazine hybrid …

Synthesis, characterizations, antitumor and antimicrobial evaluations of novel Mn (II) and Cu (II) complexes with NNN-tridentate s-triazine-Schiff base ligand

EM Fathalla, MAM Abu-Youssef, MM Sharaf… - Inorganica Chimica …, 2023 - Elsevier
The new s-triazine hydrazone, 2, 4-bis (morpholin-4-yl)-6-[(E)-2-[1-(pyridin-2-yl) ethylidene]
hydrazin-1-yl]-1, 3, 5-triazine,(L) ligand was used to synthesize three new metal complexes …

AMPs as anti-biofilm agents for human therapy and prophylaxis

H Shahrour, R Ferrer-Espada, I Dandache… - … Peptides: Basics for …, 2019 - Springer
Microbial cells show a strong natural tendency to adhere to surfaces and to colonize them by
forming complex communities called biofilms. In this growth mode, biofilm-forming cells …

Treatment strategies targeting persister cell formation in bacterial pathogens

F Khan, DTN Pham, N Tabassum… - Critical Reviews in …, 2020 - Taylor & Francis
Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are
produced to escape the effects of antibiotics within biofilms or planktonic cell populations …

Synthesis and evaluation of biological activities of tripodal imines and β-lactams attached to the 1, 3, 5-triazine nucleus

M Bashiri, A Jarrahpour, B Rastegari, A Iraji… - Monatshefte für Chemie …, 2020 - Springer
A novel collection of tripodal β-lactam derivatives with 1, 3, 5-triazine as the central core is
presented for the first time. The diastereoselective synthesis of tris-β-lactams was achieved …