With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …

BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …

Micro-nano biorobots based on bacteria have demonstrated great potential for tumor
diagnosis and treatment. The bacterial gene expression and drug release should be …

The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

Bacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale
materials, can deliver their payload to specific regions under magnetic control, enabling …

Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

The complex gastrointestinal environment and the intestinal epithelial barrier constrain the
design and effectiveness of orally administered tumour vaccines. Here we show that outer …

Living bacteria therapies have been proposed as an alternative approach to treating a broad
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …

Advances in medical robots promise to improve modern medicine and the quality of life.
Miniaturization of these robotic platforms has led to numerous applications that leverages …