Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment

A El-Sayed, S Futaki, H Harashima - The AAPS journal, 2009 - Springer
Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of
therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides …

Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers

VP Torchilin - Advanced drug delivery reviews, 2008 - Elsevier
Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully
used for intracellular delivery of a broad variety of cargoes including various nanoparticulate …

Ligand-targeted theranostic nanomedicines against cancer

VJ Yao, S D'Angelo, KS Butler, C Theron… - Journal of Controlled …, 2016 - Elsevier
Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …

[HTML][HTML] Cell-penetrating peptides—mechanisms of cellular uptake and generation of delivery systems

S Trabulo, AL Cardoso, M Mano, MCP De Lima - Pharmaceuticals, 2010 - mdpi.com
The successful clinical application of nucleic acid-based therapeutic strategies has been
limited by the poor delivery efficiency achieved by existing vectors. The development of …

Intracellular trafficking of nonviral vectors

LK Medina-Kauwe, J **e, S Hamm-Alvarez - Gene therapy, 2005 - nature.com
Nonviral vectors continue to be attractive alternatives to viruses due to their low toxicity and
immunogenicity, lack of pathogenicity, and ease of pharmacologic production. However …

Cationic liposomes for gene delivery

S Simões, A Filipe, H Faneca, M Mano… - Expert opinion on …, 2005 - Taylor & Francis
Cationic liposome–DNA complexes (lipoplexes) constitute a potentially viable alternative to
viral vectors for the delivery of therapeutic genes. This review will focus on various …

Biomimetic strategies for targeted nanoparticle delivery

D Dehaini, RH Fang, L Zhang - Bioengineering & translational …, 2016 - Wiley Online Library
Nanoparticle‐based drug delivery and imaging platforms have become increasingly popular
over the past several decades. Among different design parameters that can affect their …

An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection

SL Lo, S Wang - Biomaterials, 2008 - Elsevier
Peptides as functional biomaterials offer the possibility of incorporating various biological
activities required for different biomedical applications. Here, we take advantage of this …

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

VA Sethuraman, YH Bae - Journal of Controlled Release, 2007 - Elsevier
A novel drug targeting system for acidic solid tumors has been developed based on ultra pH-
sensitive polymer and cell penetrating TAT. The delivery system consisted of two …