Evidence of central nervous system (CNS) exogenous opioid effects in humans has been
primarily gained through neuroimaging of three participant populations: individuals after …

It has been well-documented that the brain changes in states of chronic pain. Less is known
about changes in the brain that predict the transition from acute to chronic pain. Evidence …

Introduction Chronic lower back pain (cLBP), frequently attributed to lumbar disk herniation
(LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural …

Background Chronic pain affects nearly 20% of the US population. It is a leading cause of
disability globally and is associated with a heightened risk for suicide. The role of the central …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Chronic nonspecific low back pain (cNLBP) is a leading contributor to disease burden
worldwide that is difficult to treat due to its nonspecific aetiology and complexity. The …

Purpose Chronic low back pain (cLBP) is a recurring and intractable disease that is often
accompanied by emotional and cognitive disorders such as depression and anxiety. The …

Background Posttraumatic stress symptoms (PTSS) are commonly experienced by people
with chronic pain. Although PTSS and chronic pain are associated with similar effects on …

Chronic pain is commonly treated with long-term opioids, but the neuropsychological
outcomes associated with stable long-duration opioid use remain unclear. Here, we …

Millions of chronic (non-cancer) pain patients manage their pain with long-duration opioid
use1-3, but the neurobiological implications of stable long-term opioid consumption remain …