Pathogenesis and therapy of psoriasis
Psoriasis is one of the most common human skin diseases and is considered to have key
genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of …
genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of …
[HTML][HTML] Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
Clinical and epidemiologic studies have suggested an association between infectious
agents and chronic inflammatory disorders and cancer. Better understanding of microbial …
agents and chronic inflammatory disorders and cancer. Better understanding of microbial …
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Y Zheng, DM Danilenko, P Valdez, I Kasman… - Nature, 2007 - nature.com
Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of the
epidermis (acanthosis), infiltration of leukocytes into both the dermis and epidermis, and …
epidermis (acanthosis), infiltration of leukocytes into both the dermis and epidermis, and …
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
R Lande, J Gregorio, V Facchinetti, B Chatterjee… - Nature, 2007 - nature.com
Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-
like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but …
like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but …
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
FO Nestle, C Conrad, A Tun-Kyi, B Homey… - The Journal of …, 2005 - rupress.org
Psoriasis is one of the most common T cell–mediated autoimmune diseases in humans.
Although a role for the innate immune system in driving the autoimmune T cell cascade has …
Although a role for the innate immune system in driving the autoimmune T cell cascade has …
Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial
Background Tumour necrosis factor α (TNFα) is thought to play a part in the pathogenesis of
psoriasis. We assessed the efficacy and safety of continuous treatment with infliximab, a …
psoriasis. We assessed the efficacy and safety of continuous treatment with infliximab, a …
IL-31: a new link between T cells and pruritus in atopic skin inflammation
BACKGROUND: IL-31 is a novel T-cell–derived cytokine that induces severe pruritus and
dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL …
dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL …
Inside and out: the activities of senescence in cancer
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However,
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …
Cytokines in psoriasis
J Baliwag, DH Barnes, A Johnston - Cytokine, 2015 - Elsevier
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
JR Chan, W Blumenschein, E Murphy… - The Journal of …, 2006 - rupress.org
Aberrant cytokine expression has been proposed as an underlying cause of psoriasis,
although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in …
although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in …