Mendelian randomization: concepts and scope

RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

G Davey Smith, G Hemani - Human molecular genetics, 2014 - academic.oup.com
Observational epidemiological studies are prone to confounding, reverse causation and
various biases and have generated findings that have proved to be unreliable indicators of …

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis

J Lin, J Zhou, Y Xu - Brain, 2023 - academic.oup.com
Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple
sclerosis have been developed and widely used. However, existing medications for multiple …

Obesity and vitamin D deficiency: a systematic review and meta‐analysis

M Pereira‐Santos, PRF Costa, AMO Assis… - Obesity …, 2015 - Wiley Online Library
Over the past decade, there have been an increasing number of studies on the association
between vitamin D deficiency and anthropometric state. However, we did not identify any …

The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19

Y Xu, DJ Baylink, CS Chen, ME Reeves, J **ao… - Journal of translational …, 2020 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a
Public Health Emergency of International Concern by the World Health Organization. As of …

Metabolic syndrome and sarcopenia

H Nishikawa, A Asai, S Fukunishi, S Nishiguchi… - Nutrients, 2021 - mdpi.com
Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of
muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S) …

Vitamin D supplementation for women during pregnancy

LM De‐Regil, C Palacios, LK Lombardo… - Cochrane database …, 2016 - cochranelibrary.com
Background Vitamin D deficiency or insufficiency is thought to be common among pregnant
women. Vitamin D supplementation during pregnancy has been suggested as an …

Vitamin D and obesity: current evidence and controversies

I Karampela, A Sakelliou, N Vallianou… - Current obesity …, 2021 - Springer
Abstract Purpose of Review Evidence from observational studies suggests that obesity is
associated with low vitamin D. As both obesity and hypovitaminosis D present an alarmingly …