Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review
Three important factors, including genetics, environment factors and autoimmunity play a
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …
Genetics and rheumatoid arthritis susceptibility in Iran
S Korani, M Korani, AE Butler… - Journal of cellular …, 2019 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disorder with a number of risk factors, including
both genetic and environmental. A number of RA risk associated genomic loci has been …
both genetic and environmental. A number of RA risk associated genomic loci has been …
Investigating the GWAS‐Implicated Loci for Rheumatoid Arthritis in the Pakistani Population
Rheumatoid arthritis (RA) is a complex and multifactorial autoimmune disorder with the
involvement of multiple genetic and environmental factors. Genome‐wide association …
involvement of multiple genetic and environmental factors. Genome‐wide association …
Novel functional polymorphism on PADI-4 gene and its association with arthritis onset
D Maryam Mukhtar, D Nadeem Sheikh… - Saudi Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Background Citrullinated proteins formed by peptidyl arginine deiminases (PADIs)
deimination of arginine residues in proteins are of particular interest in arthritis …
deimination of arginine residues in proteins are of particular interest in arthritis …
Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population
Z Bagheri-Hosseinabadi, MR Mirzaei, O Esmaeili… - BMC Medical …, 2023 - Springer
Background Peptidyl arginine deiminase 4 (PADI4) has been implicated in Rheumatoid
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …
A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis
M Bashir, W Mateen, S Khurshid, JM Malik, Z Agha… - Gene, 2023 - Elsevier
Abstract The peptidylarginine-deiminase 4 (PADI4) is involved in the post-translational
catalytic conversion of arginine into citrulline. The autoantibodies including anti-citrullinated …
catalytic conversion of arginine into citrulline. The autoantibodies including anti-citrullinated …
[PDF][PDF] Studying the association between STAT4 gene polymorphism and susceptibility to rheumatoid arthritis disease: An updated meta-analysis
Background: STAT4 is a transcription factor that plays a role in various cytokine signaling
pathways and in T cell subsets differentiation. Several studies have reported STAT4 gene …
pathways and in T cell subsets differentiation. Several studies have reported STAT4 gene …
[PDF][PDF] Single Nucleotide Polymorphism of Padi4 Gene) Rs11203367 (in A Sample of Rheumatoid Arthritis Iraqi Patients
NT Khadim, AKA Al-Kazaz - Iraqi Journal of Science, 2022 - iasj.net
Rheumatoid arthritis (RA) is an inflamed chronic autoimmune disease in which genetics and
environment are the most common causative factors. Peptidyl arginine deiminase type IV …
environment are the most common causative factors. Peptidyl arginine deiminase type IV …
In-silico functional and molecular phenotypic analysis of NFKBIE (V194A), and PADI4 (G55S, V82A,G112A) gene mutations in rheumatoid arthritis
F Shan, I Ahmad, MI Rashid - Journal of Proteins and Proteomics, 2024 - Springer
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder of the joints,
influenced by various factors such as age, sex, smoking, obesity, and environmental …
influenced by various factors such as age, sex, smoking, obesity, and environmental …
Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting
environmental stimulators with the immune system. M1 macrophages are a part of immune …
environmental stimulators with the immune system. M1 macrophages are a part of immune …