CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Autoimmune diseases (ADs) are characterized by the production of autoreactive
lymphocytes, immune responses to self-antigens, and inflammation in related tissues and …

Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of
unknown etiology, although genetic and environmental factors appear to contribute to its …

Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing
and remitting flares of inflammation. However, the unpredictability of disease flares impedes …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease associated with
damage to multiple organs and glands. The most common clinical manifestations are dry …

The relationship between B cells and CD4 T cells has been carefully studied, revealing a
collaborative effort in which B cells promote the activation, differentiation, and expansion of …

CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune
clearance of infected and cancerous cells and provide long-term protection. Recent …

Rheumatoid arthritis (RA) is a chronic inflammatory synovitis-based systemic disease
characterized by invasive joint inflammation and synovial hyperplasia, which can lead to …

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T
cells that contributes to antigen recognition, immune cell maturation, and immune cell …

Chronic infection and cancer are associated with suppressed T cell responses in the
presence of cognate antigen. Recent work identified memory-like CXCR5+ TCF1+ CD8+ T …