Emerging roles of tRNA-derived fragments in cancer
M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular Cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
The life and times of a tRNA
EM Phizicky, AK Hopper - Rna, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Anatomy of four human Argonaute proteins
K Nakanishi - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …
expression post-transcriptionally. These non-coding regulatory RNAs become functional …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
LTR-retrotransposon control by tRNA-derived small RNAs
Transposon reactivation is an inherent danger in cells that lose epigenetic silencing during
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
tRNA-derived small RNA: a novel regulatory small non-coding RNA
S Li, Z Xu, J Sheng - Genes, 2018 - mdpi.com
Deep analysis of next-generation sequencing data unveils numerous small non-coding
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets
Background tRFs, 14 to 32 nt long single-stranded RNA derived from mature or precursor
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
tRNA-derived RNA fragments in cancer: current status and future perspectives
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades,
and their fundamental roles in human diseases have been well established. Transfer RNAs …
and their fundamental roles in human diseases have been well established. Transfer RNAs …
Dual RNA-seq of pathogen and host
AJ Westermann, SA Gorski, J Vogel - Nature Reviews Microbiology, 2012 - nature.com
A comprehensive understanding of host–pathogen interactions requires a knowledge of the
associated gene expression changes in both the pathogen and the host. Traditional, probe …
associated gene expression changes in both the pathogen and the host. Traditional, probe …
Biogenesis and function of transfer RNA-related fragments (tRFs)
Noncoding small RNAs arise from the various un-annotated and annotated regions of the
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …