The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Consensus paper: pathological role of the cerebellum in autism

SH Fatemi, KA Aldinger, P Ashwood, ML Bauman… - The Cerebellum, 2012 - Springer
There has been significant advancement in various aspects of scientific knowledge
concerning the role of cerebellum in the etiopathogenesis of autism. In the current …

Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients

YM Wang, CW Liu, SY Chen, LY Lu, WC Liu… - Science translational …, 2024 - science.org
Essential tremor (ET) is the most prevalent movement disorder, characterized primarily by
action tremor, an involuntary rhythmic movement with a specific frequency. However, the …

Spatiotemporal firing patterns in the cerebellum

CI De Zeeuw, FE Hoebeek, LWJ Bosman… - Nature Reviews …, 2011 - nature.com
Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

JJ White, RV Sillitoe - Nature communications, 2017 - nature.com
Theories of cerebellar function place the inferior olive to cerebellum connection at the centre
of motor behaviour. One possible implication of this is that disruption of olivocerebellar …

The oscillating central network of essential tremor

J Raethjen, G Deuschl - Clinical neurophysiology, 2012 - Elsevier
Essential tremor (ET) is a centrally driven tremor. It is meanwhile well established that it does
not emerge from one single oscillator but an oscillatory network comprising most parts of the …

[HTML][HTML] Neuroimaging essentials in essential tremor: a systematic review

S Sharifi, AJ Nederveen, J Booij, AF van Rootselaar - NeuroImage: Clinical, 2014 - Elsevier
Background Essential tremor is regarded to be a disease of the central nervous system.
Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and …

Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

AM Brown, JJ White, ME van der Heijden, J Zhou, T Lin… - Elife, 2020 - elifesciences.org
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …

FXTAS: new insights and the need for revised diagnostic criteria

E Apartis, A Blancher, WG Meissner… - Neurology, 2012 - neurology.org
Objective: Fragile X–associated tremor ataxia syndrome (FXTAS) is defined by FMR1
premutation, cerebellar ataxia, intentional tremor, and middle cerebellar peduncle (MCP) …

Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: an open label trial

T Popa, M Russo, M Vidailhet, E Roze, S Lehéricy… - Brain stimulation, 2013 - Elsevier
BACKGROUND: Cerebello-thalamo-cortical (CTC) pathways dysfunction is involved in
pathological oscillations causing tremor in essential tremor (ET). Low-frequency (1 Hz) …