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The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Consensus paper: pathological role of the cerebellum in autism
There has been significant advancement in various aspects of scientific knowledge
concerning the role of cerebellum in the etiopathogenesis of autism. In the current …
concerning the role of cerebellum in the etiopathogenesis of autism. In the current …
Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients
YM Wang, CW Liu, SY Chen, LY Lu, WC Liu… - Science translational …, 2024 - science.org
Essential tremor (ET) is the most prevalent movement disorder, characterized primarily by
action tremor, an involuntary rhythmic movement with a specific frequency. However, the …
action tremor, an involuntary rhythmic movement with a specific frequency. However, the …
Spatiotemporal firing patterns in the cerebellum
Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …
their firing rate. However, in principle, they could in addition convey messages by using …
Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
JJ White, RV Sillitoe - Nature communications, 2017 - nature.com
Theories of cerebellar function place the inferior olive to cerebellum connection at the centre
of motor behaviour. One possible implication of this is that disruption of olivocerebellar …
of motor behaviour. One possible implication of this is that disruption of olivocerebellar …
The oscillating central network of essential tremor
Essential tremor (ET) is a centrally driven tremor. It is meanwhile well established that it does
not emerge from one single oscillator but an oscillatory network comprising most parts of the …
not emerge from one single oscillator but an oscillatory network comprising most parts of the …
[HTML][HTML] Neuroimaging essentials in essential tremor: a systematic review
Background Essential tremor is regarded to be a disease of the central nervous system.
Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and …
Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and …
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …
neural signals that initiate the debilitating shakiness of different body parts remain unclear …
FXTAS: new insights and the need for revised diagnostic criteria
E Apartis, A Blancher, WG Meissner… - Neurology, 2012 - neurology.org
Objective: Fragile X–associated tremor ataxia syndrome (FXTAS) is defined by FMR1
premutation, cerebellar ataxia, intentional tremor, and middle cerebellar peduncle (MCP) …
premutation, cerebellar ataxia, intentional tremor, and middle cerebellar peduncle (MCP) …
Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: an open label trial
BACKGROUND: Cerebello-thalamo-cortical (CTC) pathways dysfunction is involved in
pathological oscillations causing tremor in essential tremor (ET). Low-frequency (1 Hz) …
pathological oscillations causing tremor in essential tremor (ET). Low-frequency (1 Hz) …