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Human papillomavirus genomics: Understanding carcinogenicity
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
[HTML][HTML] Persistent human papillomavirus infection
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …
cause disease, but rather in the adeptness of the virus to establish long-term persistent …
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
The role of integration in oncogenic progression of HPV-associated cancers
AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …
can promote the development of cancer. In these cancers, the extrachromosomal viral …
Papillomavirus immune evasion strategies target the infected cell and the local immune system
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …
Intratumoral heterogeneity and clonal evolution induced by HPV integration
K Akagi, DE Symer, M Mahmoud, B Jiang… - Cancer …, 2023 - aacrjournals.org
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …
Circulating HPV DNA as a marker for early detection of relapse in patients with cervical cancer
E Jeannot, A Latouche, C Bonneau… - Clinical Cancer …, 2021 - aacrjournals.org
Purpose: Almost all cervical cancers are caused by human papillomavirus (HPV) and
patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV ctDNA) …
patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV ctDNA) …
Multi-omics characterization of silent and productive HPV integration in cervical cancer
J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …
significant public health problem worldwide. HPV integration sites can be silent or actively …
[HTML][HTML] The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
[HTML][HTML] The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers
Simple Summary Cells infected with high-risk human papillomaviruses (HPV) can
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …