Human papillomavirus genomics: Understanding carcinogenicity

CW Nelson, L Mirabello - Tumour virus research, 2023 - Elsevier
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …

[HTML][HTML] Persistent human papillomavirus infection

AN Della Fera, A Warburton, TL Coursey, S Khurana… - Viruses, 2021 - mdpi.com
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …

The role of integration in oncogenic progression of HPV-associated cancers

AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …

Papillomavirus immune evasion strategies target the infected cell and the local immune system

C Zhou, ZK Tuong, IH Frazer - Frontiers in oncology, 2019 - frontiersin.org
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Intratumoral heterogeneity and clonal evolution induced by HPV integration

K Akagi, DE Symer, M Mahmoud, B Jiang… - Cancer …, 2023 - aacrjournals.org
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …

Circulating HPV DNA as a marker for early detection of relapse in patients with cervical cancer

E Jeannot, A Latouche, C Bonneau… - Clinical Cancer …, 2021 - aacrjournals.org
Purpose: Almost all cervical cancers are caused by human papillomavirus (HPV) and
patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV ctDNA) …

Multi-omics characterization of silent and productive HPV integration in cervical cancer

J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …

[HTML][HTML] The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis

L Mirabello, MA Clarke, CW Nelson, M Dean… - 2018 - mdpi.com
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …

[HTML][HTML] The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers

VL Porter, MA Marra - Cancers, 2022 - mdpi.com
Simple Summary Cells infected with high-risk human papillomaviruses (HPV) can
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …