Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

The immune system has evolved to mount an effective defense against pathogens and to
minimize deleterious immune-mediated inflammation caused by commensal …

Immune homeostasis is dependent on tight control over the size of a population of regulatory
T (Treg) cells capable of suppressing over-exuberant immune responses. The Treg cell …

The transcription factor Foxp3 controls the differentiation and function of regulatory T‐cells
(Treg). Studies in the past decades identified numerous Foxp3‐interacting protein partners …

CD4+ T cells, also known as T‐helper (Th) cells, play an important role in orchestrating
adaptive immune responses to various infectious agents. They are also involved in the …

As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning
to be recognized. Components that control the plasticity of CD4 T cell populations include …

Regulatory T cells (Treg cells) develop from progenitor thymocytes after the engagement of
T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular …