Alzheimer's disease failed clinical trials

S Asher, R Priefer - Life sciences, 2022 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disease typically presenting with
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …

Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc

FT Gallo, C Katche, JF Morici, JH Medina… - Frontiers in behavioral …, 2018 - frontiersin.org
Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …

Revisiting the functional anatomy of the human brain: toward a meta-networking theory of cerebral functions

G Herbet, H Duffau - Physiological Reviews, 2020 - journals.physiology.org
For more than one century, brain processing was mainly thought in a localizationist
framework, in which one given function was underpinned by a discrete, isolated cortical …

Why do we remember? The communicative function of episodic memory

JB Mahr, G Csibra - Behavioral and brain sciences, 2018 - cambridge.org
Episodic memory has been analyzed in a number of different ways in both philosophy and
psychology, and most controversy has centered on its self-referential, autonoetic character …

The neuroanatomical, neurophysiological and psychological basis of memory: Current models and their origins

E Camina, F Güell - Frontiers in pharmacology, 2017 - frontiersin.org
This review aims to classify and clarify, from a neuroanatomical, neurophysiological, and
psychological perspective, different memory models that are currently widespread in the …

Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies

D Tromp, A Dufour, S Lithfous, T Pebayle… - Ageing research …, 2015 - Elsevier
Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease

D Younan, AJ Petkus, KF Widaman, X Wang… - Brain, 2020 - academic.oup.com
Evidence suggests exposure to particulate matter with aerodynamic diameter< 2.5 μm (PM2.
5) may increase the risk for Alzheimer's disease and related dementias. Whether PM2. 5 …

[HTML][HTML] Probing and regulating dysfunctional circuits using deep brain stimulation

AM Lozano, N Lipsman - Neuron, 2013 - cell.com
Despite the best available medical treatments, many patients continue to be disabled by
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …

[HTML][HTML] Longitudinal association between hippocampus atrophy and episodic-memory decline

T Gorbach, S Pudas, A Lundquist, G Orädd… - Neurobiology of …, 2017 - Elsevier
There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

Long-chain omega-3 fatty acids improve brain function and structure in older adults

AV Witte, L Kerti, HM Hermannstädter… - Cerebral …, 2014 - academic.oup.com
Higher intake of seafish or oil rich in long-chain omega-3 polyunsaturated fatty acids (LC-n3-
FA) may be beneficial for the aging brain. We tested in a prospective interventional design …