Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …

Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …

Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …