Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Central memory T (TCM) cells patrol lymph nodes and perform conventional memory
responses on restimulation: proliferation, migration and differentiation into diverse T cell …

Abstract Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term
survival outcomes, are mostly effective in patients with immune-responsive tumors. Most …

Chemokines constitute a family of chemoattractant cytokines and are subdivided into four
families on the basis of the number and spacing of the conserved cysteine residues in the N …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Therapeutic tumor vaccines have attracted considerable attention in the past decade; they
can induce tumor regression, eradicate minimal residual disease, establish lasting immune …

Secondary lymphoid organs are integral to initiation and execution of adaptive immune
responses. These organs provide a setting for interactions between antigen-specific …

Multiple protein families, each with a distinct function, provide the traffic signals for
leukocytes. The selectin family of adhesion molecules (Figure 2) has an N-terminal domain …

The proper function of immune surveillance requires well-coordinated mechanisms in order
to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid …